Role of hepatitis B virus-induced myeloid-derived suppressor cell subsets in chronic HBV infection
10.3969/j.issn.1001-5256.2019.12.030
- VernacularTitle:HBV诱导的髓源性抑制细胞亚群及其在慢性HBV感染中的作用
- Author:
Zhihui WU
1
;
Miaomiao YANG
;
Zhengkun TU
Author Information
1. Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China)
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
myeloid-derived suppressor cells;
hepatitis B, chronic;
immunity, cellular;
T-lymphocytes
- From:
Journal of Clinical Hepatology
2019;35(12):2783-2787
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) is a member of hepadnavirus, and HBV infection may not cause direct hepatocyte lesions. Host immune response determines whether the virus can be eliminated and is a major cause of HBV-related liver diseases. Myeloid-derived suppressor cells (MDSCs) are a group of non-lymphoid immune suppressor cells originating from bone marrow and can regulate innate and adaptive immune responses under different pathological conditions. Studies have shown that chronic hepatitis B patients have a significantly higher number of MDSCs in peripheral blood than the healthy population. This article introduces the role of HBV-induced MDSC subsets in persistent HBV infection and liver pathological mechanism.
