Effect of flufenamic acid on solubility, dissolution andpharmacokinetic behavior of sorafenib in MSNM@SFN
10.16438/j.0513-4870.2018-0512
- VernacularTitle:氟灭酸对索拉菲尼纳米骨架给药系统中索拉菲尼溶解度、溶出度和体内药动学行为的影响
- Author:
Yi-fan YIN
1
;
Zhuo-yue LI
1
;
Hui LI
1
;
Yang GUO
1
;
Qiang ZHANG
1
;
Xuan ZHANG
1
Author Information
1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
- Publication Type:Research Article
- Keywords:
sorafenib loaded nanomatrix drug delivery system;
flufenamic acid;
solubility;
issolution;
bioavailability
- From:
Acta Pharmaceutica Sinica
2019;54(1):48-53
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to investigate the influence of flufenamic acid (FFA) on the solubility, dissolution and bioavailability of sorafenib (SFN) in the combined administration of the MSNM@SFN and FFA. The MSNM@SFN&FFA was prepared by mixing the MSNM@SFN with FFA. The solubility, dissolution and bioavailability of SFN in the MSNM@SFN&FFA complex was investigated in comparison with those of the MSNM@SFN. This study was performed following the National Institutes of Health guidelines for the use of experimental animals; all care and handling of animals were performed with the approval of the Experimental Animal Center of Peking University Health Science Center. The MSNM@SFN&FFA showed no significant influence on the solubility, dissolution and bioavailability of SFN when compared with the MSNM@SFN. These data indicated that FFA had almost no influence on the solubility, dissolution and bioavailability of SFN in the combined administration of MSNM@SFN and FFA, thus providing an experimental foundation for the subsequent formulation research on the combined usage of drugs.
