Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework
10.16438/j.0513-4870.2018-0826
- VernacularTitle:γ-环糊精金属有机骨架材料提高难溶性药物二氟尼柳的溶出速率
- Author:
Bi-yuan WU
1
;
Yi-xian ZHOU
1
;
Xin PAN
1
;
Gui-lan QUAN
1
;
Chuan-bin WU
1
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
- Publication Type:Research Article
- Keywords:
cyclodextrin;
metal-organic framework;
solubility;
ater-insoluble drug;
iflunisal
- From:
Acta Pharmaceutica Sinica
2019;54(1):29-35
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to prepare porous γ-cyclodextrin metal-organic framework (CD-MOF) with good biocompatibility to improve the in vitro release properties of water-insoluble drugs. Different sizes of CD-MOF were obtained by controlling the self-assembly of γ-cyclodextrin and potassium ion and the rate of crystal growth. The poorly water-soluble diflunisal (DIF) was selected as the model drug and loaded into the interior of porous CD-MOF by the impregnation method. The DIF loaded CD-MOF (DIF-MOF) was characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), nitrogen adsorption and desorption, Fourier infrared spectrometer and thermogravimetric analysis. In addition, in vitro cytotoxicity and solubilizing capability of CD-MOF were investigated. It revealed that the obtained CD-MOF was cubic-like with a narrow size distribution and high porosity. Negligible cytotoxicity was found after incubation with RAW264.7 cells. Compared with the pure CD-MOF carrier, the morphology and crystal form of DIF-MOF was not damaged during the drug loading process. Moreover, the solubility and release rate of water-insoluble DIF from the DIF-MOF were significantly increased.
