Liver alkaline phosphatase: a marker of cholestasis and bile duct injury
10.3969/j.issn.1001-5256.2016.05.052
- VernacularTitle:肝脏碱性磷酸酶：胆汁淤积和胆道损伤的标志物
- Author:
Feifei SHEN
1
;
Lungen LU
Author Information
1. Department of Gastroenterology, Shanghai First People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
- Publication Type:Research Article
- Keywords:
alkaline phosphatase;
cholestasis;
liver cirrhosis, biliary;
cholangitis, sclerosing;
review
- From:
Journal of Clinical Hepatology
2016;32(5):1026-1030
- CountryChina
- Language:Chinese
-
Abstract:
Studies show that serum alkaline phosphatase (ALP) can be used not only to evaluate cholestasis, but also as a surrogate marker to assess the severity of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and several cholestatic liver diseases. This article introduces the mechanisms of action of liver ALP in the healthy population and patients with cholestatic liver disease. In case of cholestasis caused by inflammation, acidic environment and relocation of the bile capillaries cause liver ALP deactivation and an increased accumulation of lipopolysaccharide and thus lead to aggravation and delayed healing. In the treatment of PBC and PSC, promoting the restoration of hepatocyte polarity and the elimination of bile acid through the bile capillaries and using drugs capable of adjusting the pH of bile can achieve a good anti-inflammatory effect. The effect of oral intestinal ALP in the treatment of cholestatic diseases awaits further investigations in laboratories and in clinical practice.
