Research advances in the role of autophagy in liver cells and regulation of MAPK pathway
10.3969/j.issn.1001-5256.2016.05.048
- VernacularTitle:自噬在肝脏细胞中的作用及其受MAPK通路调节的研究进展
- Author:
Na JIANG
1
;
Jian PING
;
Lieming XU
Author Information
1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
autophagy;
liver cirrhosis;
hepatocytes;
hepatic stellate cells;
mitogen-activated protein kinase;
review
- From:
Journal of Clinical Hepatology
2016;32(5):1009-1012
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a highly conservative cellular process in eukaryotes that plays an important role in nutrition and energy metabolism in the liver. It can promote the autophagy of hepatocytes and protect the hepatocytes against the adverse external stimulation, but excessive autophagy can cause autophagic cell death of hepatocytes. Hepatic stellate cells (HSC) play an important role in the development and progression of liver fibrosis. Autophagy can provide energy for their activation, but may also lead to their death. This article introduces the relationship of autophagy with hepatocytes/HSC and the mitogen-activated protein kinase pathway, and points out that in-depth studies on the relationship between autophagy and pathway regulation during liver fibrosis can provide new targets for developing antifibrotic drugs.
