Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
10.3969/j.issn.1001-5256.2016.05.046
- VernacularTitle:骨形态发生蛋白7/Smads信号通路及其在肝纤维化进程中的作用
- Author:
Fei， HOU
1
;
Chenghong YIN
Author Information
1. Department of Infection, Beijing Friendship Haspital, Capital Medical University, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
bone morphogenetic proteins;
Smad proteins;
transforming growth factor beta1;
review
- From:
Journal of Clinical Hepatology
2016;32(5):1001-1004
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein-7 (BMP-7) and the downstream Smads can antagonize the effect of transforming growth factor-β1, which induces hepatic fibrosis, through various pathways, including inducing the degradation of extracellular matrix, inhibiting cell apoptosis, reducing the expression of various proinflammatory factors, and promoting the regeneration of hepatocytes. This article investigates the role of BMP-7/Smads signaling pathway in hepatic fibrosis.
