Research advances in innate immunity against hepatitis B virus
10.3969/j.issn.1001-5256.2016.05.044
- VernacularTitle:HBV天然免疫的研究进展
- Author:
Fengli LI
1
;
Juan HUA
;
Yinping LU
Author Information
1. Department of Infectious Diseases, Institute of Infection and Immunity, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
immunity, natural;
review
- From:
Journal of Clinical Hepatology
2016;32(5):992-996
- CountryChina
- Language:Chinese
-
Abstract:
When hepatitis B virus (HBV) invades the human body, innate immunity acts the earliest and plays an important role. When an adult is infected with HBV, HBV can often be eliminated spontaneously. However, if HBV infection occurs right after birth or when the patient is young, the disease tends to become chronic and affect the whole life. In the incipient stage of HBV infection, innate immune response plays an important role in inhibiting viral replication, and the prognosis of HBV infection depends on the combined effect of host and virus. This article briefly introduces the research advances in the cells, cytokines, and signaling pathways that play important roles in the host's innate immunity against HBV and their mechanisms of action, and points out their potential values in clinical treatment.
