Effect of endoscopic injection of cyanoacrylate in treatment of acute esophageal and gastric variceal bleeding in children
10.3969/j.issn.1001-5256.2016.05.024
- VernacularTitle:经内镜注射氰基丙烯酸酯治疗儿童急性食管-胃底静脉曲张破裂出血的效果观察
- Author:
Xiaoxing ZHANG
1
;
Qian LI
;
Kailong YANG
Author Information
1. Pediatric Intensive Care Unit, Children′s Hospital of Baoji Maternal and Child Health Care Hospital, Baoji, Shaanxi 721000, China
- Publication Type:Research Article
- Keywords:
esophageal and gastric varices;
endoscopy, digestive system;
cyanoacrylate;
child
- From:
Journal of Clinical Hepatology
2016;32(5):925-927
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect and safety of endoscopic injection of cyanoacrylate in the treatment of esophageal and gastric variceal bleeding (EGVB) in children. MethodsThe clinical data of 35 children with acute EGVB who were treated with endoscopic injection of cyanoacrylate in Children′s Hospital of Baoji Maternal and Child Health Care Hospital from August 2010 to August 2015 were analyzed retrospectively. The emergency response rate, rebleeding rate, and incidence of complications after the treatment were analyzed statistically. ResultsThirty-five patients received 46 times of endoscopic injection of cyanoacrylate in total. The response rate to the initial injection was 95.6% (44/46). The volume of cyanoacrylate injected was 0.2-0.6 ml, with a mean volume of 0.4±0.2 ml. The emergency hemostasis rate was 93.4% (43/46), the rebleeding rate was 11.4% (4/35), and the cycle for 4 patients with the recurrence of bleeding to be cured was 1.2-23.0 months (mean 121±10.9 months). One patient experienced abdominal pain, and no patients experienced ectopic embolism. Two patients died after injection. ConclusionFrequent, small-volume endoscopic injection of cyanoacrylate is an effective and convenient therapeutic method for EGVB in children, has few complications, and holds promise for clinical application.
