Effect of sorafenib combined with thalidomide on angiogenesis in chick chorioallantoic membrane
10.3969/j.issn.1001-5256.2016.05.019
- VernacularTitle:索拉非尼和沙利度胺单独及联合用药对鸡胚绒毛尿囊膜血管生成的影响
- Author:
Zhenya GUO
1
;
Junfeng YE
;
Qiankun XIE
Author Information
1. Department of Hepatobiliary and pancreatic Surgery, The First Hospital of Jilin University, Changchun 130021, China)
- Publication Type:Research Article
- Keywords:
antiangiogenesis inhibitors;
drug screening assays, antitumor;
chick embryo
- From:
Journal of Clinical Hepatology
2016;32(5):908-910
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of sorafenib and/or thalidomide on angiogenesis in chick chorioallantoic membrane (CAM). MethodsWhite eggs incubated for 7 days were used to establish a CAM model. The model eggs were randomly divided blank control group, sorafenib group, thalidomide group, and sorafenib/thalidomide group. After treatment, each egg was incubated for another 2 days. The CAM samples were collected and fixed to take their pictures under a microscope, and the vascular coverage of each sample was calculated. Comparison between these groups was made by analysis of variance, and comparison between each two groups was made by SNK-q test. ResultsThe thalidomide group or sorafenib group had significantly lower vascular coverage than the blank control group (30.2%±2.9% or 26.5%±2.1% vs 38.3%±2.7%, P＜0.05). The sorafenib/thalidomide group had significantly lower vascular coverage than the thalidomide group or sorafenib group (12.6%±1.5% vs 30.2%±2.9% or 26.5%±2.1%, P＜0.05). ConclusionBoth sorafenib and thalidomide have a good anti-angiogenic effect on CAM, but a combination of the two drugs shows better efficacy.
