Research advances in sorafenib-induced apoptotic signaling pathways in liver cancer cells
10.3969/j.issn.1001-5256.2016.04.048
- VernacularTitle:索拉非尼诱导肝癌细胞凋亡信号通路的研究进展
- Author:
Chaoya ZHANG
1
;
Xiangxuan ZHAO
;
Zaiming LU
Author Information
1. Department of Radiology, China Medical University Shengjing Hospital, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
sorafenib;
apoptosis;
signal transduction;
review
- From:
Journal of Clinical Hepatology
2016;32(4):816-820
- CountryChina
- Language:Chinese
-
Abstract:
Currently, sorafenib is the multi-target inhibitor for the treatment of advanced primary liver cancer, and can effectively prolong the progression-free survival and overall survival in patients with advanced primary liver cancer. The application of sorafenib in the targeted therapy for liver cancer has become a hot topic. Major targets or signaling pathways include Raf/Mek/Erk, Jak/Stat, PI3K/Akt/mTOR, VEGFR and PDGFR, STAT, microRNA, Wnt/β-catenin, autolysosome, and tumor-related proteins, and sorafenib can regulate the proliferation, differentiation, metastasis, and apoptosis of liver cancer cells through these targets. This article reviews the current research on the action of sorafenib on these targets or signaling pathways to provide useful references for further clinical research on sorafenib.
