Role of pyruvate kinase muscle isozyme 2 in pathogenesis and diagnosis of liver cancer
10.3969/j.issn.1001-5256.2016.04.046
- VernacularTitle:丙酮酸激酶M2在肝癌发病及诊疗中的作用
- Author:
Wangjiu CIDAN
1
;
Xiangxuan ZHAO
;
Xiaoming WANG
Author Information
1. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
pyruvate kinase；liver neoplasms；review
- From:
Journal of Clinical Hepatology
2016;32(4):806-810
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, studies have shown that the expression of pyruvate kinase muscle isozyme 2 (PKM2) is increased significantly in various tumor cells. PKM2 acts like a signal molecule in tumor cells and participates in the expression and regulation of genes related to tumor cell proliferation, cell autophagy, and cell cycle progression. This article summarizes the expression of PKM2 in liver cancer tissues and cell lines, elaborates on the role of PKM2 in the proliferation, differentiation, and metastasis of liver cancer cells and prognostic evaluation, and points out that PKM2 can be used in the clinical diagnosis, treatment, and prognostic evaluation of liver cancer.
