Association between nonalcoholic fatty liver disease and malignant transformation of hepatocytes
10.3969/j.issn.1001-5256.2016.03.037
- VernacularTitle:非酒精性脂肪性肝病与肝细胞恶性转化的关系
- Author:
Juanjuan GU
1
;
Min YAO
;
Dengfu YAO
Author Information
1. Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
- Publication Type:Research Article
- Keywords:
fatty liver;
liver neoplosms review
- From:
Journal of Clinical Hepatology
2016;32(3):565-569
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by diffuse macrovesicular steatosis and excessive lipid accumulation in the liver due to nonalcoholic reasons and other specific factors for liver injury, including simple fatty liver, nonalcoholic steatohepatitis, and liver cirrhosis. With the increasing incidence of NAFLD, the risk of hepatocellular carcinoma (HCC) is also increasing, but the exact mechanism remains unknown. This paper summarizes the roles of lipid accumulation, related cells, proteins, hormones, and metabolites in malignant transformation of hepatocytes, as well as the relationship between NAFLD, HCC, and lipid metabolism, and provides a new perspective for the prevention of HCC in clinical practice.
