Research advances in susceptibility genes and their role in the pathogenesis of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2016.03.009
- VernacularTitle:非酒精性脂肪性肝病相关易感基因及其在发病机制中的作用
- Author:
Shiying XUAN
1
;
Chen YUAN
;
Linlin LU
Author Information
1. Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266021, China
- Publication Type:Research Article
- Keywords:
fatty liver;
genctic predisposition to disease;
polymorphism, single nucleotide
- From:
Journal of Clinical Hepatology
2016;32(3):446-452
- CountryChina
- Language:Chinese
-
Abstract:
Currently the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing, and the age of onset is getting younger worldwide, resulting in a heavy economic burden for both individuals and the society. Since NAFLD is closely related to heredity, metabolism, and the environment, genetic factors play an important role in the development and progression of NAFLD. With the development and wide application of the techniques from the genome-wide association studies, new research advances have been achieved in the susceptibility genes of NAFLD. This review summarizes the related research findings at home and abroad, and investigates the pathogenic factors for NAFLD and related mechanisms with a focus on the polymorphisms of susceptibility genes.
