Role of cell senescence in development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2016.03.008
- VernacularTitle:细胞衰老在非酒精性脂肪性肝病发生发展中的作用
- Author:
Jing ZHANG
1
;
Bingyuan WANG
;
Junping SHI
Author Information
1. Department of Geriatric Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
- Publication Type:Research Article
- Keywords:
fatty liver;
cell aging;
liver cirrhosis;
carcinoma, hepatocellular
- From:
Journal of Clinical Hepatology
2016;32(3):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by fatty degeneration of hepatocytes due to nonalcoholic reasons. Liver cirrhosis and hepatocellular carcinoma are two important outcomes of NAFLD. Cell senescence is a relatively stable state in which cells deviate from the normal cell cycle and experience an irreversible loss of proliferative capacity, which is an objective law in cell life. Research shows that cell senescence is closely associated with the progression of liver fibrosis and the development and progression of hepatocellular carcinoma in NAFLD, and provides a new perspective for the prevention and treatment of liver fibrosis and hepatocellular carcinoma.
