The role of hepatocyte nuclear factor 4 alpha in development and progression of liver diseases
10.3969/j.issn.1001-5256.2016.02.045
- VernacularTitle:肝细胞核因子4α在肝脏疾病发生发展中的作用
- Author:
Jinlian YANG
1
;
Yan WANG
Author Information
1. Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
liver diseases;
hepatocyte nuclear factor 4;
review
- From:
Journal of Clinical Hepatology
2016;32(2):397-403
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocyte nuclear factor 4 alpha (HNF4α), a member of the nuclear receptor superfamily, has a high expression level in mature hepatocytes. HNF4α can regulate hepatocyte-specific gene expression at a transcriptional level, promote hepatocyte development and differentiation, participate in establishment and maintenance of hepatocyte polarity, and enhance the synthetic, metabolic, and detoxifying functions of the liver. Through inhibiting the activation of hepatic stellate cells, reversing epithelial-mesenchymal transition, and inhibiting the proliferation, invasion, and metastasis of hepatoma cells, HNF4α may be involved in the development and progression of various liver diseases including liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. This paper elaborates on the biological functions of HNF4α, and summarizes and analyzes the research advances in the mechanisms of action of HNF4α in the pathological process of liver diseases, in order to provide references for further investigation of the potential targeted therapies for liver diseases.
