Research advances in the pathogenesis of drug-induced liver injury
10.3969/j.issn.1001-5256.2016.02.041
- VernacularTitle:药物性肝损伤发病机制的研究进展
- Author:
Xin XU
1
;
Lisha JI
;
Linlin LU
Author Information
1. Dalian Medical University, Dalian, Liaoning 116044, China)
- Publication Type:Research Article
- Keywords:
liver diseases;
review
- From:
Journal of Clinical Hepatology
2016;32(2):382-385
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with an increasing number of drug types and unreasonable drug use, the incidence and mortality of drug-induced liver injury (DILI) have been increasing. The pathogenesis of DILI is complex, and may involve liver injury caused by the direct effect of drugs, immune-mediated liver injury, mitochondrial injury, and bile duct injury, etc. This article investigates the pathogenesis and its important role in the prevention and treatment of DILI, and reviews the research advances in the pathogenesis of DILI.
