Role of T-helper cell 17 in the development and progression of hepatocellular carcinoma

VernacularTitle:辅助性T淋巴细胞17在肝细胞癌发生发展中的作用
Author: Feifei ZHANG ¹ ; Hui CHEN ; Jun LYU
Author Information

1. Department of Hepatopathy and Cancer Biotherapy, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
Publication Type:Research Article
Keywords: carcinoma, hepatocellular; T-lymphocyte subsets; review
From: Journal of Clinical Hepatology 2016;32(8):1626-1629
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. How to improve cure rate and reduce recurrence and metastasis of HCC have always been hot topics in research. T-helper cell 17 (Th17), an important subset of CD4+ T-helper cells, plays a critical role in infection, autoimmune response, and tumor microenvironment. This article introduces the discovery of Th17 and related cytokines, summarizes its mechanisms of action and clinical significance in the development and progression of HCC, and provides some clues for new targets in the treatment of HCC and prognosis prediction.