Regulatory effect of interleukin-10 on natural killer cells in patients with chronic hepatitis B
10.3969/j.issn.1001-5256.2016.08.040
- VernacularTitle:白细胞介素10对慢性乙型肝炎患者自然杀伤细胞的调控作用
- Author:
Liang ZHOU
1
;
Xiaoyan LI
;
Yuehua HUANG
Author Information
1. Hepatopathy Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
hepatitis B, chronic;
interleukin-10;
killer cells, natural;
review
- From:
Journal of Clinical Hepatology
2016;32(8):1600-1603
- CountryChina
- Language:Chinese
-
Abstract:
At present, it is very difficult to cure chronic hepatitis B (CHB) with current therapeutic methods. Natural killer (NK) cells are an important part of innate immunity and play an important role in immune surveillance and early anti-infectious immune process. Interleukin-10 (IL-10) is a multifunctional negative regulatory factor and is involved in the biological regulation of immune cells and inflammatory cells. This article introduces the features and functions of IL-10 and NK cells, the association of CHB with IL-10 and NK cells, and the value of IL-10 and NK cells in the treatment of CHB, and points out that in CHB, IL-10 exerts a negative regulatory effect on NK cells. Further investigations are needed to confirm whether the antiviral function of NK cells can be enhanced through blocking the regulatory effect of IL-10 on NK cells, and whether liver immunopathology induced by activation of NK cells can be avoided at the same time.
