Role of tumor-associated macrophages in development and progression of primary liver cancer
10.3969/j.issn.1001-5256.2016.07.048
- VernacularTitle:肿瘤相关巨噬细胞在原发性肝癌发生发展中的作用
- Author:
Wei CHEN
1
;
Yun ZHOU
;
Jianping GONG
Author Information
1. Department of Hepatobiliary Surgery, Yubei District Hospital of Traditional Chinese Medicine, Chongqing 400010, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
macrophages;
review
- From:
Journal of Clinical Hepatology
2016;32(7):1422-1424
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between inflammatory response and tumor has gained great attention in recent years. Tumor-associated macrophages (TAMs) play an important role in tumor growth, proliferation, metabolism, and metastasis. Many studies have confirmed that most TAMs have an M2 phenotype and can promote tumor growth, metabolism, metastasis, and angiogenesis in primary liver cancer. The transformation of M2 macrophages into M1 macrophages changes the biological manifestations of hepatoma cells, which may become a new therapeutic strategy for liver cancer. This article reviews the research advances in the association between TAMs and the progression of primary liver cancer, as well as possible therapeutic regimens.
