Association between hepatitis B virus pre-S/S gene variants and HBV-related liver diseases
10.3969/j.issn.1001-5256.2016.07.044
- VernacularTitle:HBV前S/S区变异与HBV相关肝病的关系
- Author:
Mingqi YAO
1
;
Jie CHEN
;
Jing ZHANG
Author Information
1. Second Department of Liver Disease, The Second Hospital of Yuncheng, Yuncheng, Shanxi 044000, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
hepatitis B surface antigens;
mutation;
liver diseases;
review
- From:
Journal of Clinical Hepatology
2016;32(7):1406-1408
- CountryChina
- Language:Chinese
-
Abstract:
The pre-S/S gene variants of hepatitis B virus (HBV) cause various pathological and clinical outcomes. Occult hepatitis B, fulminant hepatitis or liver failure, HBsAg- and HBsAb-positive HBV infection, and primary liver cancer are all associated with HBV pre-S/S gene variants, which are involved in the development and progression of these HBV-related diseases. This article introduces the association between HBV pre-S/S gene variants and the development and progression of HBV-related liver diseases, reviews the results of related clinical and basic research, and emphasizes the controversial issues in current research, in order to provide clues for further studies.
