New immunotherapeutic strategies for chronic hepatitis B
10.3969/j.issn.1001-5256.2016.07.042
- VernacularTitle:慢性乙型肝炎免疫治疗新策略
- Author:
Shi LIU
1
;
Shanhong TANG
;
Xiaozhu ZHONG
Author Information
1. Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
hepatitis B, chronic;
immunotherapy;
review
- From:
Journal of Clinical Hepatology
2016;32(7):1398-1402
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B (CHB) is one of the most important infectious diseases around the world. Currently, interferon and nucleos(t)ide analogues are the main drugs for CHB and have good therapeutic efficacy, but the ultimate goal of eliminating hepatitis B virus (HBV) in human body has not been achieved. Therefore, it is of vital importance to explore new therapeutic strategies and develop new drugs for CHB. Persistent HBV infection is closely associated with human body′s immune status, and studies have shown that immunotherapy may help to cure CHB. With reference to CHB patients′ immune status, this article reviews the research advances in new immunotherapeutic strategies including Toll-like receptor agonists, cell therapy, and therapeutic vaccines.
