Role of follicular helper T cells in development and progression of liver diseases
10.3969/j.issn.1001-5256.2016.06.050
- VernacularTitle:滤泡辅助性T淋巴细胞及其在肝脏疾病发生发展中的作用
- Author:
Longshan JI
1
;
Xuehua SUN
;
Zhenhu ZHOU
Author Information
1. Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
liver diseases;
T-lympholytes, helper-inducer;
review
- From:
Journal of Clinical Hepatology
2016;32(6):1230-1234
- CountryChina
- Language:Chinese
-
Abstract:
Follicular helper T cell (TFH) is a new CD4+ T lymphocyte subset which helps B lymphocytes to produce antibodies and is closely related to the development and progression of liver diseases. This article reviews the detection and differentiation of TFH and related functional molecules, the mechanism of action of TFH in helping B lymphocytes to produce antibodies through producing interleukin-21, as well as the role of TFH in liver diseases such as chronic hepatitis B, chronic hepatitis C, autoimmune hepatitis, primary biliary cirrhosis, hepatic failure, and liver transplantation, and points out that TFH may become the new target cell in the treatment of liver diseases.
