Immunological characteristics of tumor antigen specific T cells and their possible mechanisms in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2016.06.048
- VernacularTitle:肝细胞癌相关抗原特异性T淋巴细胞的研究进展
- Author:
Yuli HOU
1
;
Yonghong ZHANG
;
Yan ZHAO
Author Information
1. Clinical Laboratory Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
carcimoma, hepatocellular;
antigen, neoplasm;
T-lymphocytes;
review
- From:
Journal of Clinical Hepatology
2016;32(6):1220-1224
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is a major health problem around the world and its morbidity is increasing year by year. HCC has a low rate of early diagnosis and advanced HCC has a low survival rate. Therefore, the diagnosis and treatment of HCC has attracted great attention, and tumor specific T cell immunity plays an important role in it. This article describes the immunological characteristics of seven HCC-associated antigen specific T cells, i.e., alpha fetal protein, phosphatidylinositol proteoglycan-3, NY-ESO-1, SSX-2, melanoma antigen gene A, telomerase reverse transcriptase, and HCC-associated antigen-519/target protein xklp-2, and analyzes the possible mechanisms which affect antigen specific T cell immunity from the aspects of regulatory T cells, myeloid-derived suppressor cells, antigen presenting and processing, inhibitory receptors, and CD4+T cells.
