Clinical Utility of Prominent Hypointense Signals in the Draining Veins on Susceptibility-Weighted Imaging in Acute Cerebral Infarct: As a Marker of Penumbra and a Predictor of Prognosis.
10.13104/jksmrm.2014.18.4.332
- Author:
Hyun Sil LEE
1
;
Kook Jin AHN
;
Hyun Seok CHOI
;
Jin Hee JANG
;
So Lyung JUNG
;
Bum Soo KIM
;
Dong Won YANG
Author Information
1. Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. ahn-kj@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Cerebral infarction;
Magnetic resonance (MR);
Susceptibilty-weighted imaging (SWI);
Prominent hypointense signals in the draining veins (PHSV)
- MeSH:
Brain;
Cerebral Infarction;
Follow-Up Studies;
Humans;
Infarction;
Magnetic Resonance Imaging;
Perfusion;
Prognosis*;
Veins*
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2014;18(4):332-340
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: A relative increase in deoxyhemoglobin levels in hypoperfused tissue can cause prominent hypointense signals in the draining veins (PHSV) within areas of impaired perfusion in susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of SWI in patients with acute cerebral infarction by evaluating PHSV within areas of impaired perfusion and to investigate the usefulness of PHSV in predicting prognosis of cerebral infarction. MATERIALS AND METHODS: In 18 patients with acute cerebral infarction who underwent brain MRI with diffusion-weighted imaging and SWI and follow-up brain MRI or CT, we reviewed the presence and location of the PHSV within and adjacent to areas of cerebral infarction qualitatively and measured the signal intensity difference ratio of PHSVs to contralateral normal appearing cortical veins quantitatively on SWI. The relationship between the presence of the PHSV and the change in the extent of infarction in follow-up images was analyzed. RESULTS: Of the 18 patients, 10 patients showed progression of the infarction, and 8 patients showed little change on follow-up imaging. On SWI, of the 10 patients with progression 9 patients showed peripheral PHSV and the newly developed infarctions corresponded well to area with peripheral PHSV on initial SWI. Only one patient without peripheral PHSV showed progression of the infarct. The patients with infarction progression revealed significantly higher presence of peripheral PHSV (p=0.0001) and higher mean signal intensity difference ratio (p=0.006) comparing to the patients with little change. CONCLUSION: SWI can demonstrate a peripheral PHSV as a marker of penumbra and with this finding we can predict the prognosis of acute infarction. The signal intensity difference of PHSV to brain tissue on SWI can be used in predicting prognosis of acute cerebral infarction.
