Research advances in the role of aquaporins in liver fibrosis and liver cirrhosis
10.3969/j.issn.1001-5256.2016.06.041
- VernacularTitle:水通道蛋白在肝纤维化及肝硬化进程中的作用
- Author:
Qiang ZHANG
1
;
Xiangxuan ZHAO
;
Wei SUN
Author Information
1. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
aquaporins;
review
- From:
Journal of Clinical Hepatology
2016;32(6):1192-1195
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is the final outcome of various chronic liver diseases, and various cells, cytokines, and miRNAs are involved in the development and progression of liver fibrosis and liver cirrhosis. Hepatic fibrosis and pathologic angiogenesis are interdependent processes and promote each other, but the physiopathological mechanism of arterial capillary proliferation in liver fibrosis remains unknown. Aquaporins not only transport water molecules, but also promote angiogenesis. This article briefly introduces the expression of aquaporins in the hepatobiliary system and their physiological and biochemical characteristics and summarizes the role of aquaporins in the progression of liver fibrosis and liver cirrhosis, in order to provide new thoughts and guidance for aquaporins as the target in the treatment of liver fibrosis and liver cirrhosis.
