Advances in diagnosis and treatment of primary biliary cholangitis
10.3969/j.issn.1001-5256.2016.10.046
- VernacularTitle:原发性胆汁性胆管炎诊治进展
- Author:
Zhenying ZHANG
1
;
Yuping WANG
;
Yongning ZHOU
Author Information
1. Department of Gastroenterology & Key Laboratory for Gastrointestinal Diseases of Gansu, The First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis, biliary;
diagnosis;
therapy;
review
- From:
Journal of Clinical Hepatology
2016;32(10):2016-2020
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis is an organ-specific chronic cholestatic autoimmune liver disease characterized by intrahepatic cholestasis, presence of anti-mitochondrial antibody in circulating blood, and progressive and non-suppurative damage of small intrahepatic bile ducts, which finally lead to extensive hepatic duct damage, biliary cirrhosis, and even liver failure. This article overviews the advances in the epidemiology, pathogenesis, diagnosis, and treatment of primary biliary cholangitis and points out that the safety and efficacy of the new drugs such as fibrates in the treatment of primary biliary cholangitis need to be confirmed by further studies.
