Role of circulating microRNAs in development and progression of liver fibrosis
10.3969/j.issn.1001-5256.2016.10.042
- VernacularTitle:循环血microRNA在肝纤维化发生发展中的作用
- Author:
Lifen ZHANG
1
;
Hongyu YU
Author Information
1. Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
microRNAs;
review
- From:
Journal of Clinical Hepatology
2016;32(10):2001-2003
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have found that microRNAs (miRNAs) can be secreted via exosomes, stay outside the cells, and keep stable in circulating blood. Various studies have shown that the changes in circulating miRNAs are associated with different pathological states, suggesting that the circulating miRNAs can be used as potential molecular targets for the diagnosis and treament of diseases. Research has shown that miRNAs are closely associated with the development and progression of liver fibrosis. This article reviews the studies on the differences in the expression of circulating miRNAs in the course of liver fibrosis and points out that circulating microRNAs can provide a new research direction for early noninvasive diagnosis and treatment of liver fibrosis.
