Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases
10.3969/j.issn.1001-5256.2016.10.040
- VernacularTitle:调节性T淋巴细胞和辅助性T淋巴细胞17在HBV相关性肝病中的作用
- Author:
Yan ZHOU
1
;
Xiang JING
;
Zhengyan ZHU
Author Information
1. The Third Central Clinical College, Tianjin Medical University, Tianjin 300170, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
T-lymphocytes, regulatory;
T-lymphocytes, helper-inducer;
review
- From:
Journal of Clinical Hepatology
2016;32(10):1994-1997
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the role of immune cells in hepatitis B virus (HBV)-related liver diseases has attracted more and more attention. This article reviews the roles of regulatory T cells (Treg) and T-helper cell type 17 (Th17) in the development, progression, and prognosis of HBV-related liver diseases, especially HBV-related liver fibrosis and liver failure, as well as hepatocellular carcinoma. It is pointed out that the dynamic changes of Treg and Th17 cells in different stages of HBV infection and their roles in hepatocellular carcinoma need further investigation, and future studies on the regulatory effects of various signaling pathways on Treg or Th17 cells are needed to provide a more precise direction for the treatment of HBV-related diseases.
