Related immune manifestations in patients with chronic hepatitis B virus and chronic hepatitis C virus infection
10.3969/j.issn.1001-5256.2016.10.009
- VernacularTitle:慢性HBV/HCV感染人群伴随的免疫相关表现
- Author:
Peihao LIU
1
;
Huiying RAO
Author Information
1. Peking University People′s Hospital & Peking University Hepatology Institute, Beijing 100044, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
hepacivirus;
autoimmune diseases
- From:
Journal of Clinical Hepatology
2016;32(10):1870-1873
- CountryChina
- Language:Chinese
-
Abstract:
Patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are frequently complicated by autoimmune disorders, which is commonly seen in patients with hepatitis C. This article introduces the mechanism of immune disorders in patients with chronic hepatitis C, the proportion of patients with non-organ specific autoantibody, and the clinical manifestations, diagnosis, and treatment of related immune diseases, such as mixed cryoglobulinemia, glomerulonephritis, Sjogren's syndrome, thyroid disease, and type 2 diabetes, as well as the mechanism of immune disorders, related immune manifestations, and effect of antiviral therapy in patients with chronic hepatitis B. Antiviral therapy for chronic hepatitis B and C can alleviate related immune diseases, but interferon therapy is not appropriate. Therefore, the patients with hepatitis B should be treated with nucleos(t)ide analogues, while those with hepatitis C should be treated with direct-acting antiviral agents.
