Research progress in biomarkers of drug-induced liver injury
10.3969/j.issn.1001-5256.2016.09.043
- VernacularTitle:药物性肝损伤相关生物学标志物的研究进展
- Author:
Pei GUO
1
;
Wang LU
;
Wenxuan YANG
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130000, China
- Publication Type:Research Article
- Keywords:
drug-induced liver injury;
biological markers;
review
- From:
Journal of Clinical Hepatology
2016;32(9):1822-1826
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury (DILI) is a major reason for the recall of marketed drugs and the failure of clinical trials. Detection of potential liver injury remains a challenge for clinical management and preclinical drug safety studies. Currently, serum levels of alanine aminotransferase and aspartate aminotransferase are the gold standards for evaluating liver injury. However, these biomarkers are nonspecific and insensitive, and often result in false-positive results. Therefore, researchers have never stopped searching for the biomarkers of DILI with high sensitivity and specificity. This review summarizes recent research progress in the biomarkers of DILI to better predict and diagnose DILI.
