Role of uric acid in the development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2016.09.041
- VernacularTitle:尿酸在非酒精性脂肪性肝病发生发展中的作用
- Author:
Shaofeng LI
1
;
Xianhua LIAO
;
Junzhao YE
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:Research Article
- Keywords:
fatty liver;
uric acid;
review
- From:
Journal of Clinical Hepatology
2016;32(9):1814-1818
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal uric acid metabolism is closely associated with the development and progression of nonalcoholic fatty liver disease (NAFLD). This article describes the relationship between uric acid and the prevalence and severity of NAFLD, and point out that uric acid metabolic disorders directly affect the development and progression of NAFLD through complicated pathways such as insulin resistance, oxidative stress, direct influence on the expression of lipid synthetase, and inflammatory response. Control of uric acid is expected to become one of the multimodality therapies for NAFLD.
