The role of fluoxetine in antiviral therapy for chronic hepatitis C
10.3969/j.issn.1001-5256.2016.09.036
- VernacularTitle:氟西汀在慢性丙型肝炎抗病毒治疗中的作用
- Author:
Yuan QIN
1
;
Ying ZHANG
;
Jieru ZHAO
Author Information
1. Center of Diagnosis and Treatment for Infectious Diseases of PLA, Tangdu Hospital, Fourth Military Medical University, Xi′an 710038, China
- Publication Type:Research Article
- Keywords:
hepatitis C, chronic;
fluoxetine;
molecular mechanisms of pharmacological action;
review
- From:
Journal of Clinical Hepatology
2016;32(9):1794-1796
- CountryChina
- Language:Chinese
-
Abstract:
More than 20% of chronic hepatitis C (CHC) patients receiving the antiviral therapy with interferonα(IFNα) experience depression, and fluoxetine is often used to alleviate this symptom. Fluoxetine has anti-inflammatory properties and can change the synthesis of liver lipids, but its influence on antiviral therapy for CHC and related mechanism remain unknown. Recent studies show that fluoxetine can inhibit hepatitis C virus (HCV) infection and reduce the production of reactive oxygen species (ROS) and lipid accumulation in Huh7.5 cells; in addition, it can promote the antiviral effect mediated by IFNα through activating STAT1 and JNK signaling pathways and thus reduce HCV viral load and the level of alanine aminotransferase in CHC patients. Fluoxetine elevates PPAR response element activity in CHC patients, and its inhibitory effect on HCV infection and lipid accumulation were partly reversed by antagonists including PPARβ/γ, suggesting that fluoxetine inhibits HCV infection, ROS production, and lipid accumulation through regulating PPARβ/γ and JNK/STAT pathways.
