Value of indocyanine green test in evaluating liver reserve function in patients with hepatitis B cirrhosis
10.3969/j.issn.1001-5256.2016.09.021
- VernacularTitle:吲哚菁绿清除试验对乙型肝炎肝硬化患者肝脏储备功能的评估价值
- Author:
Ruimin LAI
1
;
Mingfang WANG
;
Yueyong ZHU
Author Information
1. Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
- Publication Type:Research Article
- Keywords:
hepatitis B;
liver cirrhosis;
indocyanine green
- From:
Journal of Clinical Hepatology
2016;32(9):1739-1742
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate liver reserve function in patients with hepatitis B cirrhosis using indocyanine green (ICG) clearance test, and to investigate the correlation of ICG clearance test with Child-Turcotte-Pugh (CTP) class and the Model for End-Stage Liver Disease (MELD) score in evaluating liver function. MethodsA total of 127 patients with hepatitis B cirrhosis who were hospitalized in The First Affiliated Hospital of Fujian Medical University from January 2012 to January 2015 were enrolled. ICG clearance test was performed for all the patients, and the ICG plasma clearance (K value), effective liver blood flow (EHBF), and ICG retention at 15 minutes (ICG R15) were calculated. CTP class and MELD score were also determined. An analysis of variance was used for comparison between groups, the least significant difference t-test was used for comparison between any two groups, Spearman rank correlation was performed for correlation analysis, and the area under the receiver operating characteristic (ROC) curve was used to compare liver reserve function. ResultsAmong all the patients with hepatitis B cirrhosis, 63 had CTP class A, 45 had CTP class B, and 19 had CTP class C hepatitis B cirrhosis. With the increasing CTP class, ICG R15 gradually increased, while EHBF and K value gradually decreased (F=14696，9126 and 4094，P=0001,0003 and 0005). In the evaluation of liver function, ICG R15 was positively correlated with MELD score and CTP class (r=0.525 and 0.838, both P＜0.01) and was negatively correlated with EHBF and K value (r=-0.703 and -0.901, both P＜0.01). The area under the ROC curve was 0.85 for ICG R15 and 065 for MELD score. ConclusionICG test can accurately and dynamically reflect liver reserve function, and ICG R15 can evaluate liver reserve function better than CTP class and MELD score.
