Mechanism of action of direct-acting antiviral agents in treatment of chronic hepatitis C
10.3969/j.issn.1001-5256.2016.09.013
- VernacularTitle:直接抗病毒药物治疗慢性丙型肝炎的作用机制
- Author:
Xiaoyu WEN
1
;
Junqi NIU
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
hepatitis C, chronic;
antiviral agents;
therapy
- From:
Journal of Clinical Hepatology
2016;32(9):1699-1705
- CountryChina
- Language:Chinese
-
Abstract:
With the development and launch of direct-acting antiviral agents (DAAs) in the world in recent years, therapeutic regimens for chronic hepatitis C are constantly evolving. DAAs will also be launched in China in the near future. DAAs mainly target at the non-structural proteins of HCV and can inhibit HCV RNA replication. This article introduces the targets, mechanism of action, and resistance characteristics of different DAAs, as well as their current research and development in China and the results of phase Ⅲ clinical studies, in order to provide a reference for combined therapeutic strategies with DAAs in the treatment for chronic hepatitis C.
