Definition, pathophysiology, and clinical management of acute-on-chronic liver failure
10.3969/j.issn.1001-5256.2016.09.010
- VernacularTitle:慢加急性肝衰竭的定义、病理生理学基础和临床管理
- Author:
Haixia LIU
1
;
Yueke ZHU
;
Qinghua MENG
Author Information
1. Department of Critical Care Medicine of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
liver failure;
pathophysiology;
disease management
- From:
Journal of Clinical Hepatology
2016;32(9):1684-1687
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is defined as rapid deterioration of liver function under acute attack in patients with chronic liver disease and is associated with an extremely high mortality. Since the basis of liver disease and potential pathogenic factors for acute injury are different in Chinese and Western medicine, the diagnosis remains controversial. However, there is a consensus on the fact that the condition of ACLF can be reversed, and early diagnosis and reasonable treatment can improve prognosis. This article introduces the pathophysiology of ACLF from the aspects of risk factors, predisposing factors, response after injury, and organ failure and elaborates on the reasonable management measures to improve patients′survival rate.
