Role of chymotrypsin C in development and progression of pancreatitis and pancreatic cancer
10.3969/j.issn.1001-5256.2016.11.051
- VernacularTitle:糜蛋白酶C在胰腺炎和胰腺癌发生发展中的作用
- Author:
Zejie LIU
1
;
Yilin SONG
;
Hong LI
Author Information
1. Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi′an 710038, China
- Publication Type:Research Article
- Keywords:
chymotrypsin;
pancreatitis;
pancreatic neoplasms;
review
- From:
Journal of Clinical Hepatology
2016;32(11):2222-2225
- CountryChina
- Language:Chinese
-
Abstract:
Chymotrypsin C (CTRC) is a trypsinogen synthesized by pancreatic acinar cells and secreted by pancreatic duct cells and belongs to the family of serine chymotrypsin. The main function of CTRC is to regulate the balance between activation and degradation of trypsin and maintain the structural and functional integrity of the pancreas. CTRC gene mutations can cause abnormal activation of trypsinogen and abnormal degradation of trypsin and then lead to the development of pancreatitis. The downregulation or absence of CTRC expression may be associated with the development and metastasis of pancreatic cancer. This article introduces the structure and biological function of CTRC and its mechanism of action in the development and progression of pancreatitis and pancreatic cancer.
