Diagnostic value of H19 gene in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2016.11.046
- VernacularTitle:H19基因对肝细胞癌的诊断价值
- Author:
Shimei WANG
1
;
Xia WU
;
Peng KANG
Author Information
1. Department of Infectious Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
RNA, untranslated;
diagnosis;
review
- From:
Journal of Clinical Hepatology
2016;32(11):2203-2205
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that some long non-coding RNAs (lncRNAs) are expressed abnormally in hepatocellular carcinoma (HCC) tissue, and the expression of H19 gene in lncRNAs in HCC tissue is significantly higher than that in normal tissue. After the knockout of H19 gene, the proliferative and invasive abilities of HCC are significantly reduced. This article briefly introduces lncRNAs and H19 gene, the detection method for lncRNAs, and the value of H19 in the diagnosis of HCC and points out that H19 may be used in a method for the diagnosis of HCC. Further studies on the expression of H19 in HCC and rapid, simple, and economic detection of lncRNAs including H19 play important roles in the diagnosis of HCC.
