Regulatory effect of transforming growth factor-β on activation of hepatic stellate cells
10.3969/j.issn.1001-5256.2016.11.044
- VernacularTitle:转化生长因子β对肝星状细胞活化的调控作用
- Author:
Weihua ZHAO
1
;
Yanhong WANG
;
Min CONG
Author Information
1. Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
transforming growth factor beta;
hepatic stellate cells;
review
- From:
Journal of Clinical Hepatology
2016;32(11):2195-2198
- CountryChina
- Language:Chinese
-
Abstract:
In the process of liver fibrosis, transforming growth factor β (TGFβ) is considered an important regulatory factor for the activation of hepatic stellate cells (HSCs) and extracellular matrix production. Therefore, the therapeutic strategies targeted at the activation of HSCs and liver fibrosis induced by TGFβ are worthy of further research. This article reviews the role of TGFβ in the activation of HSCs, the regulatory effect of TGFβ, and the therapeutic strategies targeted at the activation of HSCs induced by TGFβ, so as to provide a theoretical basis and new thoughts for the clinical treatment of liver fibrosis.
