Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms
10.3969/j.issn.1001-5256.2016.11.042
- VernacularTitle:肝细胞内源性microRNA与HBV交互作用影响HBV转录的机制
- Author:
Hua QIU
1
;
Xuehua SUN
;
Zhenhu ZHOU
Author Information
1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China
- Publication Type:Research Article
- Keywords:
microRNAs;
hepatitis B virus;
transcription, genetic;
review
- From:
Journal of Clinical Hepatology
2016;32(11):2186-2190
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus (HBV) transcription and replication. This article summarizes the miRNAs with an anti-HBV effect in hepatocytes and 4 regulatory mechanisms, as well as the mechanisms through which HBV affects the expression of endogenous miRNAs in hepatocytes via HBx and self-coding miRNAs and promotes replication. The analyses show that the interaction between endogenous miRNAs and HBV in hepatocytes forms a complex regulatory network, competes for the results of regulation, and determines the activity of HBV transcription and the trend of disease progression. In-depth studies on the mechanisms of the influence of interaction between endogenous miRNA and HBV in hepatocytes on HBV transcription have great significance in exploring new anti-HBV methods.
