Guiding significance of Guideline for diagnosis and treatment of herb-induced liver injury in clinical diagnosis: a retrospective analysis
10.3969/j.issn.1001-5256.2016.11.032
- VernacularTitle:《中草药相关肝损伤临床诊疗指南》指导临床诊断的回顾性分析
- Author:
Yun ZHU
1
;
Ruilin WANG
;
Xueying SUN
Author Information
1. Treatment and Research Center for Combined TCM and Western Medicine, 302 Hospital of PLA, Beijing 100039, China
- Publication Type:Research Article
- Keywords:
drug-induced liver injury;
drugs, Chinese herbal;
retrospective studies
- From:
Journal of Clinical Hepatology
2016;32(11):2159-2162
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical guiding significance of Guideline for diagnosis and treatment of herb-induced liver injury in the diagnosis of herb-induced liver injury (HILI). MethodsA retrospective analysis was performed for the clinical data of 595 hospitalized patients who were admitted to 302 Hospital of PLA from January 2009 to January 2014 and diagnosed with HILI according to HILI diagnostic strategies recommended by American College of Gastroenterology. The chi-square test was used for comparison of categorical data between groups. ResultsAccording to the Guideline for diagnosis and treatment of HILI, all 595 patients (100%) were diagnosed with suspected HILI, 234 (39.3%) were diagnosed with clinical HILI, and 52(8.7%) were diagnosed with definite HILI. Among the patients with clinical and definite HILI, 85.0% and 94.2%, respectively, had a clinical type of cell injury, and 52.6% and 423%, respectively, had a severe disease. There were no significant differences in prognosis between the patients with suspected, clinical, and definite HILI, and 81.5%, 82.5%, and 80.8%, respectively, were cured. ConclusionGuideline for diagnosis and treatment of HILI can effectively guide the diagnosis of HILI, avoid misdiagnosis in clinical practice, and guarantee the safe application of Chinese herbal medicine. Its clinical guiding significance in the diagnosis of HILI awaits more prospective studies.
