Advances in research and development of new drugs for antiviral therapy for chronic hepatitis B
10.3969/j.issn.1001-5256.2016.11.005
- VernacularTitle:慢性乙型肝炎抗病毒治疗新药研发进展
- Author:
Yanhang GAO
1
;
Peiyan LIU
;
Pujun GAO
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
hepatitis B， chronic;
antiviral agents;
therapy
- From:
Journal of Clinical Hepatology
2016;32(11):2043-2049
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus (HBV) infection is one of the major disease burdens worldwide. At present, the antiviral therapy for hepatitis B includes interferons and nucleos(t)ide analogues. Current therapeutic regimens based on these drugs cannot significantly increase the proportion of patients with functional cure. With a better understanding of HBV replication cycle and specific virus-host cell interactions, this article summarizes and reviews the advances in the research and development of new drugs for HBV with a focus on different action targets during the above processes.
