Research advances in signaling pathways involved in liver regeneration mediated by oval cells
10.3969/j.issn.1001-5256.2016.12.037
- VernacularTitle:卵圆细胞介导肝脏再生信号通路的研究进展
- Author:
Xiaomao ZHONG
1
;
Baosheng HAN
Author Information
1. Department of Reproduction and Genetics, The Affiliated Hospital of North China University of Science and Technology & Tangshan Women and Children′s Hospital, Tangshan, Hebei 063000, China
- Publication Type:Research Article
- Keywords:
hepatic oval cells;
liver regeneration;
signal transduction;
review
- From:
Journal of Clinical Hepatology
2016;32(12):2399-2402
- CountryChina
- Language:Chinese
-
Abstract:
The apoptosis, necrosis, and senescence of hepatocytes are closely associated with the activation and proliferation of oval cells, and in addition, liver regeneration mediated by oval cells is an important part of regeneration after liver injury. Currently, studies have shown that a variety of cytokines, hormones, and neurotransmitters are involved in this process. This article reviews recent research findings, introduces the research advances in the association between various signaling pathways (TWEAK/Fn14, Hedgehog, and thyroid hormone) and liver regeneration mediated by oval cells, elaborates on the role of each pathway in the regeneration of hepatocytes, and investigates related mechanisms in liver regeneration.
