Role of the Mac-2 binding protein glycosylation isomer in diagnosis of chronic liver diseases
10.3969/j.issn.1001-5256.2016.12.036
- VernacularTitle:Mac-2结合蛋白糖基化异构体在慢性肝病诊断中的作用
- Author:
Yiliang YANG
1
;
Yuanyuan CUI
;
Yu HU
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
liver diseases;
biological markers;
glycoproteins;
diagnosis;
review
- From:
Journal of Clinical Hepatology
2016;32(12):2395-2398
- CountryChina
- Language:Chinese
-
Abstract:
Mac-2 binding protein is a type of glycoprotein which exits in cytoplasm, interstitial fluid, and plasma and is secreted by a variety of tissues and organs. Mac-2 binding protein glycosylation isomer (M2BPGi) is synthesized by hepatic stellate cells. This article briefly introduces the research advances in the role of M2BPGi in chronic liver diseases and finds out that the serum level of M2BPGi helps to increase the specificity and sensitivity of the diagnosis and monitoring of liver diseases, has certain advantages over other noninvasive methods, and may become a new biological marker for the diagnosis of liver diseases.
