Role of intestinal mucosal barrier in the development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2016.12.035
- VernacularTitle:肠道黏膜屏障在非酒精性脂肪性肝病发生发展中的作用
- Author:
Yuanyuan ZHANG
1
;
Jing LI
;
Yujing CHI
Author Information
1. Department of Gastroenterology, People′s Hospital, Peking University, Beijing 100044, China
- Publication Type:Research Article
- Keywords:
fatty liver;
interobacteriaceae;
review
- From:
Journal of Clinical Hepatology
2016;32(12):2391-2394
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing year by year in China. Intestinal mucosa is the largest organ for bacterial storage, and intestinal mucosal barrier includes biological barrier, mechanical barrier, immunological barrier, and chemical barrier. This article investigates the important role of intestinal mucosal barrier function in the pathogenesis of NAFLD. As for the intestinal biological barrier, abnormalities in gut microbiota occur earlier than obesity and other metabolic disorders; small intestinal bacterial overgrowth may affect energy metabolism, promote insulin resistance, and get involved in the pathogenesis of NAFLD; regulation of gut microbiota has a certain clinical effect in the treatment of NAFLD. Intestinal mechanical barrier impairment increases the mucosal permeability and is associated with intestinal dysbacteriosis. The changes in intestinal immunological barrier may be associated with obesity, metabolic disorders, and liver inflammation. The changes in intestinal chemical barrier can inhibit the synthesis and secretion of very low-density lipoprotein and low-density lipoprotein in hepatocytes and may result in triglyceride deposition in the liver. It is pointed out that the research on intestinal mucosal barrier function provides promising prospects for the prevention and treatment of NAFLD.
