PD-1/PD-L signaling pathway in chronic hepatitis B
10.3969/j.issn.1001-5256.2016.12.031
- VernacularTitle:PD-1/PD-L信号通路在慢性HBV感染免疫反应中的作用
- Author:
Lilin TAO
1
;
Xin LAI
;
Jia WEI
Author Information
1. Department of Gastroenterology, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China
- Publication Type:Research Article
- Keywords:
hepatitis B, virus;
hepatitis B, chronic;
programmed death 1;
review
- From:
Journal of Clinical Hepatology
2016;32(12):2373-2379
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B is one of the major diseases that affect the health of Chinese people, and chronic hepatitis B virus (HBV) infection can lead to disease progression. Programmed death-1 (PD-1) discovered in recent years is an important coordinated stimulus molecule which belongs to the B7/CD28 family. After its binding with programmed death ligand (PD-L), it can regulate the activation, differentiation, and proliferation of T lymphocytes. PD-1 and its ligand are differently expressed in different stages of chronic HBV infection. The interaction between PD-1 and its ligand in different immune cells induces immune tolerance in human body and finally leads to the chronicity of HBV infection. Blocking the PD-1/PD-L signaling pathway through different ways can improve T cell exhaustion, suggesting that this might be one of the directions of antiviral therapy in future.
