Research advances in the application of specific molecular probes for positron emission tomography in diagnosis of early-stage liver fibrosis
10.3969/j.issn.1001-5256.2016.12.009
- VernacularTitle:PET特异性分子探针在肝纤维化早期诊断中的应用
- Author:
Mengyi YANG
1
;
Xiangxin XU
;
Jun XIN
Author Information
1. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
liver fibrosis;
positron-emission tomography;
molecular probes;
diagnosis
- From:
Journal of Clinical Hepatology
2016;32(12):2273-2276
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a symbolic process of many chronic liver diseases, and liver biopsy is the gold standard for the diagnosis of liver fibrosis in clinical practice. At present, there is a lack of effective methods for the noninvasive diagnosis of early-stage liver fibrosis. The process of liver fibrosis is accompanied by complicated changes at the molecular level, which are associated with the progression of liver fibrosis. As an imaging examination which can provide the information at the molecular level such as tissue function and metabolism, positron emission tomography (PET) has the ability to monitor such quantitative information. This article mainly introduces the principles of specific molecular probes for PET used in the diagnosis of early-stage liver fibrosis, summarizes the value of these specific molecular probes in the diagnosis and staging of early-stage liver fibrosis, and points out that it is necessary to find more specific molecular probes for the diagnosis of early-stage liver fibrosis.
