Progress in the combined application of bone morphogenetic protein-2 and basic fibroblast growth factor in bone tissue engineering
10.12016/j.issn.2096⁃1456.2018.05.009
- Author:
LIN Weimin
1
,
2
,
3
;
CHEN Miao
1
,
2
,
3
;
HU Chen,
1
,
2
,
3
;
QU Yili
1
,
2
,
3
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases &
3. Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
Bone morphogenetic protein-2;
Basic fibroblast growth factor;
Growth factors;
Combined application;
Bone tissue engineering;
Bone regeneration
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2018;26(5):325-329
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) are two important signaling molecules for natural bone repair that are widely applied in the field of bone tissue engineering. BMP-2 accelerates the maturation and mineralization of osteoblasts, and bFGF exhibits significant effects on the promotion of cell division and angiogenesis. The osteogenesis mechanism of BMP-2 differs from that of bFGF, leading to a potentially complementary role between the two proteins. The use of a suitable dose of bFGF in combination with BMP-2 in bone tissue engineering synergistically promotes the formation of new bone and exhibits a better repair effect than either single growth factor. However, the suitable dose range of BMP-2 and bFGF in combination should be further clarified. The mechanism of the synergism and antagonism between BMP-2 and bFGF must be further delineated, and a drug delivery system that better simulates the growth factor release pattern during natural bone repair remains to be designed.
- Full text:骨形成蛋白-2与碱性成纤维细胞生长因子联合应用于骨组织工程研究进展1.pdf
