Association between uric acid and brachial-ankle pulse wave velocity among hypertensive population in rural areas of Eastern China
10.16462/j.cnki.zhjbkz.2019.04.015
- Author:
Jing-ping ZHANG
1
;
Jing-jing CAO
;
Bin-yan WANG
;
Xian-hui QIN
;
Tong-hua ZANG
;
Xi-ping XU
Author Information
1. Institute of Biomedical Research, Anhui Medical University, Hefei 230032, China
- Publication Type:Research Article
- Keywords:
Uric acid;
Brachial-ankle pulse wave velocity;
Arteriosclerosis;
Hypertension
- From:
Chinese Journal of Disease Control & Prevention
2019;23(4):441-444,458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between serum uric acid and brachial-ankle pulse wave velocity (baPWV) levels and to examine any possible effect modifiers among hypertensive patients in rural areas of Eastern China. Methods This cross-sectional study was conducted in Lianyungang and Anqing Cities from July to September 2013. Hypertensive patients with serum uric acid and baPWV measurements were included in this study. Multivariate linear regression was used to assess the relationship between serum uric acid levels and baPWV. Results Finally, a total of 4 278 participants were included in this study. The mean age was 65.2 (standard deviation(SD):7.4) years and the mean value of baPWV levels were 1835.1 (SD: 383.4) cm/s. Regression analysis showed that there is a positive correlation between serum uric acid and baPWV levels (per SD increment, β=20.5 cm/s, 95% CI: 8.5-32.5, P=0.001. When uric acid was categorized in tertiles, a significantly higher baPWV level was found in participants in tertile 3 (≥349μmol/L)(β=51.2 cm/s, 95% CI: 23.8-78.6, P=0.001), compared with those in tertile 1(<277 μmol/L). Furthermore, the serum uric acid-baPWV association was significantly stronger in those systolic blood pressure (SBP)≥140 mm Hg (vs.<140 mm Hg; p-interaction=0.001). Conclusion There is a positive relationship between uric acid levels and baPWV among hypertensive patients, especially in those with higher SBP levels.
