Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma
10.12016/j.issn.2096-1456.2019.12.012
- Author:
HUANG Lihuan
1
,
2
,
3
;
JIANG Yingtong
1
,
2
,
3
;
OUYANG Kexiong
1
,
2
,
3
;
WU Lihong
1
,
2
,
3
;
YANG Xuechao
1
,
2
,
3
Author Information
1. Affiliated Stomatological Hospital of Guangzhou Medical University·
2. Guangzhou Institute of Oral Diseases·
3. Key Laboratory of Stomatology
- Publication Type:Review
- Keywords:
oral squamous cell carcinoma;
oncogene;
microRNA;
miR-155;
epstein-barr virus(EBV);
human papillomavirus(HPV);
target gene;
biomarker
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2019;27(12):809-812
- CountryChina
- Language:Chinese
-
Abstract:
Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Previous studies have found significantly high miR-155 expression in OSCC. However, the mechanism by which miR-155 plays a role in OSCC oncogenesis is not yet clear. This article reviews the function of the relationship between miR-155 and tumors and the potential role of miR-155 in the development of OSCC. A literature review showed that mir-155, as a small carcinogenic RNA, can inhibit CDC73, BCL6, P27Kip1 and other target genes that play a role in cancer inhibition; promote the proliferation, migration and invasion of OSCC cells; and inhibit apoptosis. miR-155 can also be combined with biological factors (Epstein-Barr virus, human papillomavirus) to promote the development of OSCC.
- Full text:miR-155在口腔鳞状细胞癌发生中作用及机制研究进展.pdf
