The correlation study of serum LHB, HBsAg, HBV DNA, ALT levels and liver inflammation activity in patients with chronic hepatitis B
10.3969/j.issn.1001-5256.2015.12.016
- VernacularTitle:慢性乙型肝炎患者血清HBV外膜大蛋白、HBsAg、HBV DNA及ALT水平与肝组织炎症活动度的相关性
- Author:
Yang LI
1
;
Jianchun XIAN
Author Information
1. Department of Liver Diseases, The People′s Hospital of Taizhou, Taizhou, Jiangsu 225300, China)
- Publication Type:Research Article
- Keywords:
hepatitis B, chronic;
membrane glycoproteins;
hepatitis B surface antigens;
alanine transaminase
- From:
Journal of Clinical Hepatology
2015;31(12):2054-2056
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical significance of serum hepatitis B virus large surface protein (LHB), HBsAg, hepatitis B virus (HBV) DNA, and alanine aminotransferase (ALT) levels and their correlation with liver inflammation activity in patients with chronic hepatitis B (CHB). MethodsOne hundred and two HBeAg-positive patients with CHB who visited the People′s Hospital of Taizhou from January 2011 to December 2014 were enrolled in the study, and were divided into mild inflammation group (G0-1) and severe inflammation group (G2-4) according to the grade of liver inflammation activity. Continuous data were expressed as x±s; the t-test was applied for comparison between two groups, and analysis of variance was applied for comparison between multiple groups. The Spearman rank correlation test was applied to investigate the correlation between LHB, HBsAg, HBV DNA, and ALT levels and the grade of liver inflammation activity. The area under the receiver operator characteristic (ROC) curve (AUC) was applied to evaluate their diagnostic values. ResultsThe level of LHB tended to increase with the increasing HBV DNA. The AUCs of LHB, HBsAg, ALT, and HBV DNA for diagnosing severe liver inflammation were 0.763, 0.756, 0.702, and 0.581, respectively, and the diagnostic efficiency of LHB, HBsAg, and ALT reached a moderate level (AUC of the ROC curve 0.70-0.90); the diagnostic values of serum LHB and HBsAg levels for severe liver inflammation were higher than that of serum ALT level. The optimal cut-off for serum LHB level to diagnose severe inflammation was 24.6, and the corresponding sensitivity and specificity were 73.4% and 60.3%, respectively. ConclusionSerum LHB and HBsAg levels have certain predictive values for severe liver inflammation in HBeAg-positive patients with CHB.
